BotoxAlternative HP

Increasingly, ardent opponents and refusers of botulinum therapy appear in our offices, the reasons can be very different: from reading on the Internet .. to fear of an injection, what analogues can we offer to replace the classical botulinum therapy? After all, our patients still want to be young and radiant without wrinkles.

An innovative solution of the South Korean brand ZENA BOTOXALTERNATIVE HP, which allows, without resorting to injections of botulinum toxin type A, to relax muscles and restore the dermis, to act on the deep layers of the skin in order to restore a healthy state. attractive appearance significantly improves the quality of the patient’s skin.

Uniquely developed using high technologies and the latest advances in science, high and balanced, working in synergy, the concentration of neurotransmitter, signal, transport peptides and plant extracts determines the rapid achievement of a visible effect to eliminate static and dynamic wrinkles, launch regeneration processes, collagen stimulation, work qualitatively with texture, color, turgor and skin tone.

Often, muscle relaxants are combined with signaling and remodeling peptides in order to obtain the effect of not only relaxing muscles, but also filling wrinkles. Its peptides inhibit the formation of the Snare-SNAP complex, which affects the neurotransmitter acetylcholine, which is involved in muscle contraction. The peptides included in the composition also have a lifting effect, increase the proliferation of fibroblasts and the synthesis of collagen in the extracellular matrix.

ZENA BotoxAlnternative HP has a similar effect on botulism (without any side effects) gently reduces muscle contraction, relaxes mimic wrinkles and has a botox-like effect due to the presence of biomimetic peptides in the preparation that mimic the effect of botulinum toxin, promotes relaxation of facial muscles and reduces the superficial fine wrinkled mesh has a muscle relaxant effect when applied intradermally. Eliminates mimic wrinkles, improves the quality of the skin with fine wrinkled morphotype, helps to eliminate wrinkles in the orbital and perioral zones, neck and décolleté. Improves tissue tone and elasticity.

Effects:

Restoration of skin density

Increased tone, elasticity

Intensive lifting

Reducing the depth and width of static and dynamic wrinkles

Botoxlike effect for all age groups

 

Application protocol:

Intradermal nappage on lifting projections, dermapen, hyaluron foam (1 division, superficially), electroporation

 Frequency 1 time / 10 days from 4-10 procedures

Structure :

  Sodium hyaluronat has a pronounced moisturizing, wound healing, antioxidant effect, restores the internal environment of the dermis.

Niacinamide

 niacin amide, vitamin PP. It has been scientifically proven that it increases the production of ATP, which affects the renewal of DNA and also protects the skin from photodamage, increases the lifespan of fibroblasts, increases collagen synthesis, increases the content of lipids (by 67% fatty acids and 34% synthesis of ceramides) and proteins (by 41%) in the stratum corneum, which improves the barrier function, increases skin moisture.Fights the appearance of wrinkles, smoothes the skin microrelief, narrows enlarged pores, reduces rosacea, relieves dryness and sensitivity, has a depigmenting effect, regulates the production of sebum, has an anti-inflammatory effect on skin with moderate acne, reduces inflammation on the skin by 60%.

1,2-Hexanediol – antiseptic and moisturizing action

Adenosine the nucleoside is present in the composition of nucleic acids, It is part of some enzymes, ATP, and nucleic acids, is an inhibitory neurotransmitter, is a strong anti-inflammatory agent, and also actively affects the production of collagen elastin (stimulates the production of type 1 procollagen), evens out the skin relief, is an antioxidant

Centella asiatica leaf extract characterized by the content of alkaloids, glycosides, saponins, tannins, flavonoids. The plant extract contains vitamins E and A, magnesium.

Centella asiatica leaf extract contains madecassoside, a triterpene that stimulates collagen production in the body and has anti-inflammatory and regenerative properties,Thus, Centella asiatica leaf extract stimulates collagen synthesis, enhances blood microcirculation in the dermis, fights free radicals, accelerates cell regeneration, smoothes wrinkles, has an anti-inflammatory effect and gives the skin a firm, fresh, toned appearance, strengthens blood vessels.

Camellia Sinensis Leaf Extract high content of polyphenols – antioxidants with an anti-inflammatory effect, which play an important role in the prevention of cellular disorders, tones blood vessels and has an anti age effect.

Camellia Sinensis Leaf Extract’s ability to protect against free radicals is 20 times higher than that of vitamin E.

Houttuynia cordata extract has a pronounced anti-inflammatory, anti-edema and antimicrobial effect, inhibits the production of sebum, has a moisturizing effect on the skin, has antibacterial properties, is used for skin care, strengthens capillaries, stimulates skin cell renewal and is an antioxidant.

 Diospyros kaki leaf extract contains proanthocyanidin which slows down aging by protecting against DNA damage. Polyphenols exhibit lightening properties and provide protection against wrinkle formation by inhibiting enzyme activity. In a complex, terpenoids, flavonoids and carotenoids contained in Diospyros Kaki Leaf Extract exhibit pronounced antioxidant activity.

Diospyros Kaki Leaf Extract contains vitamins and minerals. Contains a large amount of catechin, epigallocatechin, gallocatechin, epicatechin and flavonol myricetin and gallic tannins,. It is rich in iron and also contains naphthoquinone, a precursor of vitamin K that plays a role in the coagulation process. Kaki Diospyros leaf extract contains a highly active leukoanthocyanin.Eastern persimmon leaf extract acts as an anti-free radical and natural skin brightening agent, as well as affects elasticity, tone, firmness.

Сassia cinnamon bark extract  is able to activate collagen synthesis in the skin, has a powerful antioxidant protection, has linderanolide B and subamolid A in the extract, effective depigmenting properties.

Сhrysanthella indica extract has antioxidant protection, anti-inflammatory action (used as an active ingredient in the treatment of rosacea) due to the flavonoid compounds luteolin and acacetin-7-O-rutinoside has a powerful tyrosinase inhibition.

Chaenomeles sinensis fruit extract

is a superantioxidant, an expression of the recognition of vitamin C, malic, tartronic, citric and other acids, minerals (iron, copper, zinc, phosphorus, pectins, calcium, silicon, boron), vitamins (A, E, K, B1, B2, B6, E, PP), fatty acids.

Artemisia princeps leaf extract

 has anti-inflammatory, antioxidant effect, contains coumarin derivatives: coumarin, scopoletin; flavonoids, rutin, saponins, vitamins C and group B, a large amount of mineral salts.

Tripeptide-1 peptide of three amino acids glycine-histidine-lysine, is a signal peptide, stimulates the production of collagen stimulates the production of other essential proteins: fibronectin, elastin and laminin Protects the skin from photoaging, promotes regeneration, increases skin elasticity, promotes tissue renewal by activating the synthesis of extracellular matrix proteins

palmitoyl tripeptide-1  is a messenger peptide for collagen repair. Similar in action to retinoic acid, but in comparison with retinoic acid, does not cause irritation. The peptide stimulates the synthesis of collagen and glycosaminoglycan, thereby strengthening the epidermis and reducing wrinkles.

Palmitoyl pentapeptide-4 Matrixyl® synthetic peptide with derivatives of serine, threonine and hexadecanoyl. The results of clinical studies have shown that it stimulates the synthesis of collagen (in particular, types I, III and IV), elastin and fibronectin, glycosaminoglycan.

Hexapeptide-9 (Collaxyl)the peptide helps to significantly reduce the length and depth of wrinkles and improve skin elasticity. In the same way as wrinkles, collaxil removes acne marks, stretch marks, shallow scars and scars.

Hexapeptide-9 stimulates the production of extracellular matrix, acts as an anti-age agent that reduces the severity of wrinkles and promotes accelerated skin regeneration. This peptide is clinically proven to visibly reduce the length and depth of wrinkles. stimulates the synthesis of a number of structural proteins, to be honest, collagen types I and III, as well as proteins of the dermal-epidermal layer (laminin-5, integrins, collagen IV). stimulates epidermal proliferation markers such as keratin and filaggrin.

Copper tripeptide-1 the latest generation copper peptides are considered one of the most advanced anti-aging components. has anti-inflammatory and antioxidant effects, stimulates the synthesis of structural proteins, chondroitin, decorin, and glycosaminoglycans promotes the growth of blood vessels. Renews and revitalizes the skin. Copper tripeptide-1 promotes tissue repair by activating natural extracellular matrix proteins: collagen, elastin, laminin (responsible for cell adhesion). By acting on fibroblasts, the tripeptide stimulates the synthesis of collagen 1 and 3.

Acetyl Hexapeptide-8 (Argireline) peptide which is a fragment of SNAP 25, botulinum toxin substrate is a new generation of biologically safe peptides with muscle relaxant action. Has no side effects. It is an alternative to Botulinum Toxin A, in areas where the use of botulinum toxin is not possible, or in case of resistance to botulinum toxin

ARGIRELINE mimics the N-terminal end of SNAP-25, competing with this natural protein in the SNARE-complex, which in turn consists of 3 proteins: VAMP, Syntaxin, and SNAP-25. In the case of even a slight destabilization of the SNARE complex, the release of neurotransmitters is not so efficient, and, therefore, muscle contraction is weakened, preventing the formation of wrinkles and folds.

Acetyl Hexapeptide-8 is specially formulated to combat expression wrinkles, effectively reducing wrinkles on the neck and around the eyes. It has been proven that this peptide not only effectively reduces existing wrinkles, but also prevents the formation of new wrinkles.Blocks muscle innervation due to competitive inhibition of proteins responsible for the process of nerve impulse conduction, it is not a toxin, it is physiologically absolutely safe. Argireline has been scientifically proven to reduce the depth of wrinkles, especially on the forehead and around the eyes. (Study published in the International Journal of Cosmetic Science in 2002) Its mechanism of action is that it slows down the conduction of nerve impulses to the muscles. This component induces muscle relaxation without muscle paralysis.

The principle of action of acetyl hexapeptide-8 resembles the action of botulinum toxin (botox), causing the so-called effect of botox. The peptide relaxes the muscles, causing an immediate result – a reduction in wrinkles. In addition, it prevents the formation and formation of new wrinkles.

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Lidcaine Cream Anesthetizes the skin before syringe injection or surgical treatment. Decreases male genital sensitivity. Anesthetizes the skin infected by leg ulcer before cleansing or surgical operation. Lidocaine Cream contains lidocaine, active ingredients that helps numb the skin. It is a local anesthetic cream that can be applied directly to the skin to help you feel less pain.

Efficacy / Effect: Prolonging ejaculation / Dermatology Application

Active ingredient: Each gram contains Lidocaine — 105.6mg

Warning ⚠ : Keep out of reach of children

Tight container at room temperature(1~30°C)

Avoid Applying near eyes

Only for external use

Dosage: Apply 26.4~69.7mg(as a lidocaine)

In advance of intercourse (5~15mins)

The quantity and the time of application depend on an individual so use the smallest effective dose it should not exceed maximum 184mqg{(as a lidocaine) within 24 hours

Shelf life : 3 years

Efficacy : Anesthetic cream, mainly used for laser operation, semi-permanent make-up, MTS operation, filler operation, etc. Relieving the sensitivity of tactile sense of male genital organ

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The Chaeum Premium is a series of highly-cross linked Hyaluronic Acid Filler, giving the filler a higher viscosity compared to the regular biphasic fillers.

Packing: 2 pcs in 1box

Due to cross-linking, the filler is also easy to mold and can hold its shape for a long time. This filler also contains 0.3% lidocaine content that reduces the pain during and after the procedure.

The Chaeum Premium No. 2

Hyaluronic Acid Concentration: 20 mg/mL

Crosslinking Rate: 2 out of 4

Lidocaine: 0.3%

Depth of Injection: Superficial & Mid Dermis

Shelf Life: 24 months

Areas: Forehead wrinkles, Fine lines surrounding the eyes, Small and fine wrinkles on this skin

Must be stored in a room between 1 – 25°C.

Protect it from freezing and direct sunlight.

The Chaeum Premium No. 3

Hyaluronic Acid Concentration: 20 mg/mL

Crosslinking Rate: 3 out of 4

Lidocaine: 0.3%

Depth of Injection: Mid & Deep Dermis

Shelf Life: 24 months

Areas: Nasolabial folds, Cheeks, Lips, Marionette Lines, Skin with moderate to deep wrinkles

Must be stored in a room between 2 – 25°C.

Protect it from freezing and direct sunlight.

The Chaeum Premium No. 4

Hyaluronic Acid Concentration: 20 mg/mL

Crosslinking Rate: 4 out of 4

Lidocaine: 0.3%

Depth of Injection: Subcutaneous Layer

Shelf Life: 24 months

Areas: Nose, Chin, Cheeks, Nasolabial Folds, Skin with deep wrinkles

Must be stored in a room between 2 – 25°C.

Protect it from freezing and direct sunlight.

Benefits of Using

The Chaeum Premium Holds its Shape

This filler has a high viscosity that can make it hold its shape during the procedure.

Long-Lasting

Due to the high cross-linking process, the filler lasts for a long time.

Easy to Mold

The filler has a smaller particle size, which makes it easy to mold.

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Dermaheal LL (lipolytic) solution is a powerful method of injectable lipolysis, enriched with biomimetic peptide, phosphatidylcholine, L-carnitine, which dissolves the excess fat in unreacheable places. 

The Dermaheal LL injection is the ideal solution to fight against the fat in:
– The double chin, cheeks and neck;
– The thighs and the hips;
– The area of ​​the abdomen;
– The knees, shoulders, hands and the back.

Instructions for use:
Dermaheal LL shall be injected directly into the adipose tissue, using a thin needle, in the comfort of your home and without the need for anesthesia. The non-invasive and painless procedure does not interfere with your life rhythm and is suitable for use from 2 to 4 times, in 6-8 weeks time.

Expected results:
The effect is visible after 4 weeks, which are necessary for long-lasting fat breakdown without yo-yo effect. The unique Dermaheal LL injection formula not only promotes the uniform burning of subcutaneous fat, but also the synthesis of collagen in the skin, leaving it firm and smooth.

We do not recommend using Dermaheal LL injection if:
– You suffer from skin infections, autoimmune diseases or intolerance to hyaluronic acid;
– You are breastfeeding or pregnant;
– You are visiting laser or peeling procedures at the same time.

Box contents:
5 ml x 10 vials

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Celosome is a dermal filler product line containing hyaluronic acid of non-animal origin developed specifically for customer satisfation. 

Celosome series are rpovided through

-8-phase ultra-functional technology

-Multi-way membrane for complete removal of BDDE, metal ions and foreign substances

-De-ionized facilities and ultra-pure water system to minimize imprutities and endotoxins

-HENM cross-linking technology for longer duration and optimized viscoelasticity

Celosome series provide

-Minimized swelling and allergic reactions in skin after treatment

-Immediate, stable and visible result

-Natural volumizing effect for a long time

-Perfect customers satisfaction and safety

CELOSOME 1.1ml is a filler of 100% cross-linked hyaluronic acid of non-animal origin 

Celosome AQUA,SOFT,MID,STRONG,IMPLANT.

Celsome is containing 0.3%lidocaine  for treatment of wrinkles and folds(8-phase ultra-functional technology)

Multi-way membrane for complete removal of BDDE, 

metal ions and foreign substances.De-ionized facilities HENM cross-linking technology for the longer 

duration, optimized viscoelasticity tomaintain elasticity in your skin

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Caratbody – Patent Micro Beads of Cross-linked Hyaluronic Acid

HA concentration：20 mg/ml

Ingredient：Sodium Hyaluronate Gel

Volume：10ml x 1

Area of use：Breasts and buttocks augmentation

Injection area：Deep dermis, subcutaneous tissue shallow

Storage Condition： Store at room temperature

                               Avoid direct sunlight.

                               Do not store with freezing.

Shelf Life：36 months

Patent 3 Staged Microbeads Hyaluronic Acid Cross-linked Technology（Patented MCL* technology）

This product is a sterilized product with gel-type, no toxicity by building bridge hyaluronic acid which is extracted from microorganisms.

This bridged hyaluronic acid is provided embedding in a disposable syringe, and must be injected into 1 patient only, and should not be dispensed and injected into 2 persons. The packaging quantity or capacity of the product is specified on outside the packaging box.

This product is a disposable sterile medical device, autoclaving (121 ° C, 18 minutes) and should not be reused.

Companies of conventional fillers that claim to have created a long-lasting HA filler tell us that they have achieved in raising the cross-linking rate. However, most products have only raised concentration and particle size due to limitations in the cross-linking technology. This does not contribute to longevity of the product. Moreover, products that merely increase concentration results in a product that is not easily moldable.

Caratbody applies the patented 3 staged microbead processing technology that allows to increase the viscosity and produce a long-lasting filler. By controlling the cross-linking rate to adjust the viscosity, we are able to produce a wide range of high quality fillers depending on its use.

Viscosity

Caratbody applies the unique technology of creating a semi-solid state gel of Hyaluronic Acid. Our product has high cohesiveness and viscosity so when injected it creates a pseudo capsule as an implant form that it is not easily dissolved through natural hyaluronidase by the body (mechanism of long-lasting effect).

Longevity

Increased concentration / Increased particle size

Semi-solid Gel type Caratbody

Removable

Caratbody has overcome the problems faced by increasing the cross-linking rate, to create a safe and removable product

You don’t have to worry about unsatisfactory results after injection. Caratbody is strong against natural hyaluronidase inside the body, but can be completely removed by injecting hyaluronidase. Then the filler left in the soft tissue can be completely removed. It is easily removed.

High hydrophilic capacity

Our product provides excellent volume effect through its high hydrophillic

capacity and stable molecular structure even after high cross-linking rate

Instruction for use & manipulation sequence

To achieve the desired result, the injection should be into the deep dermis. If the injection is too deep or inner layer of the muscle, the hyaluronic acid will be degrades rapidly, causing the duration time to be shortened. If the injection is too light may result in bluish discoloration of the skin or bulging.

 *For breast augmentation, injection should be done at the top part of breast. Do not inject from the bottom part of the breast, otherwise ptosis or sagging may occur.

Contraindication

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Etrebelle is a collagene stimulator made with biodegenerateble PLA (Poly D, L-lactide) microparticles and Hyaluronic acid.

Etrebelle is a hybrid filler that has adopted both benefits of the immediate filling effect o HA and stimulating collagene production of PLA under the skin. Based on the idea of delivering PLA (Poly D, L-lactide) microparticles by HA (Sodium Hyaluronate), not only physical supports under the skin, Etrebelle improves the fundamental deficiency of volume loss by collagene restoration.

Right after injection, Etrebelle takes a position and instantly supports the wrinkled area with its HA material. Meanwhile, included PLA microparticles help HA not to migrate from the target area by giving extra cohesiveness.

After 1 month, while HA starts t be degraded, PLA microparticles promote collagene production and lead to even more elastic skin conditions. The mixture ratio of Etrebelle is remarked from this turning point of each materials` interaction under the skin.

After 6 months, the outcome of Etrebelle can be shown which has been gradually biodegenerated and restore the skin volume from physical support to newly synthesized collagen fibers maintain the natural result over time.

It is used for deep wrinkles improvement, neocollagenesis, increase skin elasticity.

Etrebelle 200 consists of PLA 170mg + HA 30 mg

PLA particle – 50-60mkm

HA particle – 3,000 kDA

Mixture: Sterile distilled water 9cc + Lidocaine 1cc (dilution time over 30 min)

Cannula size – 25-27G

Manifactured in Korea.

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S-DNA is a cell regenerating DNA treatment derived from salmon that repairs damaged and aging skin. S-DNA is injected directly into the epidermis and gradually recovers and revitalizes your skin.

S-DNA provides:

– Cell growth stimulation  – Cell proliferation (Fibroblast, Osteoblast, Chondrocyte)

– A2 receptor stimulation – Tissue repair (Anti-inflammatory effect, Microcirculation improve) 

– DNA synthesis

S-DNA induces tissue regeneration and healing properties for damaged skin cells, from the epidermis through to the deep dermis for a lasting effect. As a result, S-DNA enhances the skin’s protective barriers to keep your skin natural, healthy and firm.

S-DNA act for Tissue Regeneration & Wound Healing by:

– Whitening

– Anti-aging

– Skin restructuring

– Anti-wrinkle

– Enhancing elasticity

– Replenishing skin balance

– Rejuvenation

– Reducing the signs of acne

Experiencing the maximum effect of S-DNA is expected in 3~4 sessions, 2~3 weeks apart.

• After 3~5 days of treatment application, skin will feel soft and revitalized.

• After 2~4 weeks of treatment application, skin elasticity will improve and fine wrinkles lifted .

• After 4~6 weeks of treatment application, skin volume is enhanced along with lifting effects.

Precautions

• Do not use on infected wounds (such as the wounds with redness, pus, warmth, swelling, etc.).

• Do not use the product if you experience a rash, fever, allergic reactions, or symptoms of an infection appears while using the product and you should consult your doctor or pharmacist for the most appropriate treatment.

• Use according to your doctor’s instructions if you are hypersensitive to polynucleotide.

• Do not overuse. • If you are pregnant or breastfeeding, or if you suspect or are planning to become pregnant, consult your doctor or pharmacist before use

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ReNTox 200 is a popular product in many countries around the world. Manufactured by a well-known South Korean company (Pharma Research BIO Co., Ltd.). This drug is very popular, it is highly effective at a low cost of drug cost. Rentox, like other Korean botulinum toxins, has been highly appreciated by cosmetologists and patients.

Indications for use:

Botulinum toxin injections are used not only in cosmetology, but also in medicine.

1- The first signs of aging and the appearance of mimic wrinkles.

2- Excessive sweating.

3- Correction of the shape of the lips.

4- Hypotension and skin atony.

5- Thinning and lethargy of the skin.

6- Gravitational ptosis.

7- Post-acne.

8- Prevention and correction of cicatricial changes in the skin.

9- Fine wrinkled type of skin aging.

10- Preparation for plastic surgery.

11- Preparation with medium and deep peels.

Release form: 1 bottle / 200 units. The drug is a lyophilized white powder for injection, in a colorless transparent bottle, when diluted with saline, it is a clear liquid.

Storage conditions: Store between 2 C and 8 C

Expiration date: 36 months from the date of manufacture.

Manufacturer: PharmaResearch BIO Co., Ltd., South Korea.

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ReNTox 100 is a popular product in many countries around the world. Manufactured by a well-known South Korean company (Pharma Research BIO Co., Ltd.). This drug is very popular, it is highly effective at a low cost of drug cost. Rentox, like other Korean botulinum toxins, has been highly appreciated by cosmetologists and patients.

Indications for use:

Botulinum toxin injections are used not only in cosmetology, but also in medicine.

1- The first signs of aging and the appearance of mimic wrinkles.

2- Excessive sweating.

3- Correction of the shape of the lips.

4- Hypotension and skin atony.

5- Thinning and lethargy of the skin.

6- Gravitational ptosis.

7- Post-acne.

8- Prevention and correction of cicatricial changes in the skin.

9- Fine wrinkled type of skin aging.

10- Preparation for plastic surgery.

11- Preparation with medium and deep peels.

Release form: 1 bottle / 100 units. The drug is a lyophilized white powder for injection, in a colorless transparent bottle, when diluted with saline, it is a clear liquid.

Storage conditions: Store between 2 C and 8 C

Expiration date: 36 months from the date of manufacture.

Manufacturer: PharmaResearch BIO Co., Ltd., South Korea.

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